Research use
For laboratory applications
Worldwide delivery
International shipping available
Technical information
Detailed specifications included
Netrin receptor DCC Rabbit Polyclonal Antibody
Catalog:0992-0911-5
Available sizes
1 optionAvailability
Stock products usually ship within 24–48 hours. Non-stock products may require approximately 2–6 weeks.
Shipping conditions
No dry-ice requirement is indicated for this product.
Hazardous classification
This product is not currently marked as hazardous.
Netrin receptor DCC (deleted colorectal careinoma) was originally identified as a putative tumor suppressor gene that is lost in more than 70% of colorectal cancers. The DCC protein is a type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Native DCC is found in three isoforms. Two forms, a long and a short isoform, are produced from the same gene but have different initiation sites. The third isoform, produced by alternative splicing, is expressed only in embryonic tissue. Colorectal tumors that lost their capacity to differentiate into mucus producing cells uniformly lack DCC expression. Inactivation of DCC due to allelic deletion or point mutations may cause both lymphatic and hematogenous metastasis of esophageal squamous cell carcinomas.
This product is intended for laboratory and research use only. Review the supplied documentation before use.
Product Name
Netrin receptor DCC Rabbit Polyclonal Antibody
Catalog Number
0992-0911-5
Available Sizes
100 µL
Hazardous
No
Dry Ice
No
Host
Rabbit
Isotype
IgG
Species Reactivity
- Human
- Mouse
Abbreviation
DCC
Alternative Name
Colorectal cancer related chromosome sequence 18 antibody Colorectal cancer suppressor antibody CRC 18 antibody CRC18 antibody CRCR 1 antibody CRCR1 antibody DCC antibody DCC_HUMAN antibody Deleted in colorectal cancer protein antibody Deleted in colorectal carcinoma antibody Immunoglobulin superfamily DCC subclass member 1 antibody Netrin receptor DCC antibody Tumor suppressor protein DCC antibody
Applications
WB, IF-Cell, IHC-P, FC
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Cas
9007-83-4
Cellular Locus
Cell membrane
Concentration
1 mg/mL
Conjugation
Non-conjugated
Dilution
WB: 1:500-1:1,000
Form
Liquid
Immunogen
Recombinant protein with of Human Netrin receptor DCC aa 21-299 / 1447.
Molecular Weight
Predicted band size: 90 kDa
Positive Control
Human brain, mouse brain
Purity
Immunogen affinity purified.
Recombinant Antibody
No
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Swiss Prot
P43146 Human
Type
Rabbit polyclonal Antibody