Research use
For laboratory applications
Worldwide delivery
International shipping available
Technical information
Detailed specifications included
Human ITPRIPL1 Protein, His Tag
Catalog:0716-IT1-H52H3-100ug
Available sizes
1 optionAvailability
Stock products usually ship within 24–48 hours. Non-stock products may require approximately 2–6 weeks.
Shipping conditions
No dry-ice requirement is indicated for this product.
Hazardous classification
This product is not currently marked as hazardous.
Inositol 1,4,5-triphosphate receptor interacting protein like 1 (ITPRIPL1) is a single transmembrane protein, exhibits normal testis-enriched expression and widespread overexpression in various human cancers. ITPRIPL1 is commonly found in tumors with low PD-L1 expression. ITPRIPL1 acts as a natural ligand for CD3 ε, evading immune surveillance, leading to decreased T cell activity and promoting tumor growth. Research has shown that inducing stable CD3E-NCK1 binding prevents CD3E-ZAP70 interaction, subsequently inhibiting downstream ERK-NFkB signaling cascade and calcium influx activation.
This product is intended for laboratory and research use only. Review the supplied documentation before use.
Product Name
Human ITPRIPL1 Protein, His Tag
Catalog Number
0716-IT1-H52H3-100ug
Available Sizes
100 µg
Hazardous
No
Dry Ice
No
Host
HEK293
Accession Number
Q6GPH6
Additives
Trehalose
Background
Inositol 1,4,5-triphosphate receptor interacting protein like 1 (ITPRIPL1) is a single transmembrane protein, exhibits normal testis-enriched expression and widespread overexpression in various human cancers. ITPRIPL1 is commonly found in tumors with low PD-L1 expression. ITPRIPL1 acts as a natural ligand for CD3 ε, evading immune surveillance, leading to decreased T cell activity and promoting tumor growth. Research has shown that inducing stable CD3E-NCK1 binding prevents CD3E-ZAP70 interaction, subsequently inhibiting downstream ERK-NFkB signaling cascade and calcium influx activation.
Bioactivity
Immobilized Human ITPRIPL1 Protein, His Tag (Cat. No. IT1-H52H3) at 1 μg/mL (100 μL/well) can bind ITPRIPL1 antibody with a linear range of 0.01-1.25 μg/mL (QC tested).
Buffer
PBS, pH7.4
Conjugation
Unconjugated
Datasheet
https://console.acrobiosystems.com/public/product/pdf/ds/IT1-H52H3.pdf
Endotoxin
1.0 EU per μg
Expression Region
His 25 - Gly 103
Format
Powder
Molecular Weight
11.2 kDa
Package Size
100ug*1
Purity
90%
Shipping Conditions
RT
Source
Human
Species
Human
Specifications
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 11.2 kDa. The protein migrates as 11 kDa and 13 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Stability
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Storage Conditions
-20°C
Tag
C-10xHis
Target
ITPRIPL1
Additional Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Host Or Source
HEK293
Preservative
Trehalose
Protein Id
Q6GPH6